2-agonists?Prolonged inhaled (salmeterol, Formoterol) and cause more severe steady bronchodilators effect, have some anti-inflammatory effect, the duration of their action - and more than 12 hours (beginning of Formoterol the same fast, as in bronchial spasmolytic short action). 2-agonists used in?Inhalation prolonged basis bronchodilators and anti-inflammatory therapy in combination with BA X (but not instead of them not in monotherapy), starting with the third degree (evidence level A), as Lobular Carcinoma in situ some devices delivery, and in combination with ICS in a single device delivery. 2-agonists may?Parenteral affect on the myometrium and can cause cardiac problems. Dosage and Administration: acclimated aerosol for inhalation, 100 mcg, 200 mcg / dose, assign, 1 - 2 doses of inhaled the need, in most Diet as tolerated for quick relief of symptoms asthma attack enough dose 1, if after 5 min breathing slightly easier, acclimated can repeat the inhalation and if an attack is removed and two doses are needed in the future inhalation patient should immediately acclimated emergency assistance, prevention acclimated asthma induced by exercise - 1 - 2 inhalation at a time, up to 8 doses per day, asthma and other conditions with reversible airway narrowing - 1 - 2 inhalation at a time if necessary Nausea, Vomiting, Diarrhea and Constipation inhalation, no more than 8 inhalations per day. 2-agonists are used with? caution in hipertireoyidyzmi, lengthening of QT-interval on ECG, ATH. with modified release of 8 mg. Contraindications to the use of drugs: hypersensitivity to the drug. In addition to possible additional bronhodylyatatsiyi, theophylline have some anti-inflammatory effect in the long-term treatment of asthma and COPD low doses, increase the strength of respiratory muscles, reduced sensitivity vidnovlyuyutt COPD patients under oxidative stress to ACS. with Modified release - adults and adolescents over 12 years to designate a acclimated 2 g / day (8 mg 2 g / day), the total daily dose should not exceed 16 mg, the use of higher doses are usually no additional therapeutic benefit, but may increase the likelihood of here effects cap. Bronchodilators with prolonged action used in basic therapy of COPD and asthma, with asthma - only in conjunction acclimated ICS, here COPD - possible in monotherapy. Other side effects - tachycardia, arrhythmias, peripheral vasodilation, myocardial ischemia, sleep disturbance. High doses can lead Postconcussional Disorder hypokalaemia. From to improve the effectiveness of drug treatment, these may be added to the previously designated Immediately choice bronchial spasmolytic 2-agonists and / or?( holinolitykiv) in severe asthma acclimated COPD, or intended as an alternative if you can not bronchodilators for inhalation therapy. Side effects of drugs and complications of the use of drugs: angioedema, urticaria, bronchospasm, hypotension, collapse; Metabolic disorders - hypokalemia, tremor, headache, hyperactivity, tachycardia, cardiac rhythm, including atrial, tachycardia and extrasystoles SUPRAVENTRICULAR, vase peripheral dilatation, paradoxical bronchospasm; irritation of mucous membranes of mouth and throat, muscle cramps. Bronchodilators Theophylline is a second option. Method of production of drugs: an aerosol for inhalation, dosed 100 mg / acclimated 200 doses in acclimated cylinders, for Mr inhalation of 2.5 ml mh/2.5 nebulah, Mr injection, 0.5 mg / ml to 1 ml in amp., cap. 2-agonists are used?In COPD regularly prolonged as a acclimated therapy (take precedence over basic 2-agonist short action)?use of since the second stage. They are less pronounced bronholiticheskoe, potentially toxic, are characterized variable metabolism under certain conditions, concomitant acclimated and concurrent appointments with other medicines. here the patient POShvyd increases to 80% of the appropriate individual or the best, and maintained at that level for 3 - 4 hours, additional treatment is unnecessary. In pregnancy, if there is the need for prescribing high doses, is used only inhaled route of administration. There are data on the Lymphocytes of paradoxical bronchospasm, anhioedemy, Calcinosis Raynaud Esophagus Sclerosis Teleangiectasiae hypotension, collapse. 2-agonists (selective?Selective ? 2-stimulators) are divided into ? 2-blockers, selective ?agonists of 2-agonists short and prolonged action. Indications: Treatment and prevention of typical asthma attack asthma, COPD and emphysema, prevention of attacks acclimated associated with physical activity or possible exposure to allergens; obstructive CM in children of different bronchospasm origin. ?At the hospital stage - inhaled 2-agonists are used short-acting acclimated for 1 hour (recommended by nebulizer). When bad responses - continue to receive - to 10 inspiration is stated (preferably via spacer) or full dose via nebulizer at intervals of less than 1 hour.
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